People with a higher MPV (>or= 9.5 fL) at baseline had a higher risk of blood clots (venous thromboembolism) during the 10-year follow-up period, compared to people with a lower MPV (MPV 8.5 fL).įurthermore, two meta-analyses have found a link between heart attacks and higher MPV. In addition, several studies have linked a higher mean platelet volume (MPV) to heart attacks and deep vein clots. Larger platelets, according to research, are more active and form more blood clots. Platelet size is a factor in the formation of dangerous blood clots. Parts of these clots can also break off and travel through the bloodstream, causing severe damage and even death in the lungs, heart, and brain. Clots can form inside blood vessels, impeding blood flow to tissues. Platelets can be harmful in certain situations, causing blood clots where they aren’t needed. In a study for a group of people with suddenly reduced heart blood flow (acute coronary syndrome), MPV on average was higher in people living at high altitudes. Several studies involving hundreds of people suggest that smokers have higher MPV and that quitting smoking helps reduce it. One of the most common such disorders is thalassemia, an inherited red blood cell disorder. Some inherited genetic disorders can increase MPV. So you don’t have anything if you don’t have your MPV. Remember that MPV refers to the size of your platelets, not the number of them. Trusted Source for a variety of cancers, including: If you have a family history of cancer or other risk factors, your doctor may recommend additional testing to ensure no other symptoms.Ī high MPV blood test indicates increased platelet production, which is linked to a lower survival rate. However, having a high MPV blood test does not imply that you have cancer. Increased MPV is associated with platelet activation, which can occur when platelets contact tumour byproducts. Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder that causes antibodies to attack platelets. Higher MPV has been linked to a both underactive and overactive thyroid (hypo- or hyperthyroidism). High MPV blood test has also been associated with other metabolic disorders such as high cholesterol, diabetes, and insulin resistance. In the obese group, the MPV increased with increasing BMI. Obesity may be associated with significantly higher MPV, according to research. Studies have proved that lower blood vitamin D levels were associated with high MPV. To obtain an accurate diagnosis, consult with your doctor or another health care professional. High MPV is frequently associated with the causes listed below. Furthermore, a higher MPV value may indicate the presence of other diseases such as heart disease, hypothyroidism, stroke, or high blood pressure.Because increased MPV correlates with platelet activation, it could also be a cause of platelet activation in some cancers.As a result, a higher MPV value could mean that older platelets are being destroyed, resulting in more platelets being produced in the bone marrow.Platelets recently released from the bone marrow are larger and circulate through the bloodstream, whereas older platelets are smaller and circulate through the bloodstream.When the MPV value is high, and the total platelet count is low, it means the bone marrow is producing platelets quickly.
The total platelet count should be included as well. The MPV test result, on the other hand, cannot be interpreted on its own.
This indicates that the platelets’ average size is greater than the average.
This could be because older platelets are being destroyed, and the bone marrow is compensating. When a person’s platelet count is low, but their MPV level is high, it means their bone marrow is producing platelets quickly. Platelets that are smaller in size are more likely to have been in circulation for a few days. Larger platelets are typically younger and have just been released from the bone marrow. Platelets are made in the bone marrow and then released into the bloodstream. This could be an indication that you’re producing too many platelets.
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